1-Azido-2-(2-(2-methoxyethoxy)ethoxy)ethane (98%)

Name: 1-Azido-2-(2-(2-methoxyethoxy)ethoxy)ethane (98% purity) 

Molecular Formula: C7H15N3O3 

CAS#: 74654-06-1 

SMILES: COCCOCCOCCN=[N+]=[N-] 

MDL#: MFCD22574767 

Catalog#: AMTGC196-AM16

Molecular weight:   189.21 g/mol 

Other names: 

• 2-(2-(2-methoxyethoxy)ethoxy)ethyl azide 

Fields of Interest: PEGylating reagent, Organic Synthesis, Medicinal Chemistry 

Background & Applications: 

Background
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide (CAS 74654-06-1) is a monofunctional azide-functionalized PEG derivative based on a PEG3 backbone with a terminal azide group and a methoxy-capped end. The polyethylene glycol chain provides hydrophilicity, flexibility, and compatibility with aqueous and biological systems, while the azide functionality enables efficient bioorthogonal click chemistry, including CuAAC and strain-promoted cycloaddition reactions. The methoxy terminus renders the molecule non-reactive at one end, making it useful for controlled, single-point conjugation. This compound complements a diverse line of functionalized PEGs designed for precise and predictable molecular modification. 

Applications
This azido-terminated, methoxy-capped PEG is commonly used in bioconjugation, surface modification, and materials science applications requiring monofunctional reactivity. Typical uses include click-based attachment of PEG chains to small molecules, polymers, and surfaces to improve solubility and reduce non-specific interactions, as well as the preparation of PEGylated probes and intermediates for diagnostics and imaging. As part of a comprehensive functionalized PEG product line, 1-Azido-2-(2-(2-methoxyethoxy)ethoxy)ethane supports modular design strategies in pharmaceutical research, biomaterials, and specialty chemical development. 

Appearance: Pale yellow to amber liquid 

Purity: 98 % 

Storage: 0-3 °C for long term storage 

Solubility: DCM, THF, Acetone 

Literature: Journal of Medicinal Chemistry, 2025, vol. 68, # 2, p. 1901 – 1923.