Name: 2-(2-(2-Ethoxyethoxy) ethoxy)ethanamine (99% purity)
Molecular Formula: C8H19NO3
CAS#: 145373-80-4
SMILES: CCOCCOCCOCCN
MDL#: MFCD20696794
Catalog#: AMTGC287-AM17
Molecular weight: 177.24 g/mol
Other names:
- 2-(2-(2-ethoxyethoxy)ethoxy)ethylamine
Fields of Interest: PEGylating reagent, Organic Synthesis, Medicinal Chemistry.
Background & Applications:
Background
2-(2-(2-Ethoxyethoxy)ethoxy)ethanamine (CAS 145373-80-4) is a monofunctional amine-terminated PEG derivative based on a PEG3 backbone with a terminal primary amine and an ethoxy-capped end. The polyethylene glycol chain provides hydrophilicity, flexibility, and compatibility with aqueous systems, while the amine functionality enables efficient coupling to activated carboxylic acids, NHS esters, isocyanates, and other electrophilic groups. The ethoxy terminus renders the molecule non-reactive at one end, allowing controlled, single-point functionalization. This compound complements a diverse portfolio of functionalized PEGs designed for predictable and selective molecular modification.
Applications
This amine-terminated, ethoxy-capped PEG is commonly used in bioconjugation, drug delivery, and materials science applications where monofunctional reactivity is required. Typical uses include PEGylation of small molecules and polymers to improve solubility and stability, surface and nanoparticle modification, and preparation of intermediates for pharmaceutical and biomaterials research. As part of a comprehensive functionalized PEG product line, 2-(2-(2-Ethoxyethoxy)ethoxy)ethanamine supports modular design strategies in specialty chemical synthesis, diagnostics, and advanced materials development.
Appearance: Colorless liquid
Purity: 99 %
Storage: 0-3 °C for long term storage
Solubility: DMSO, DMF, DCM
Literature: Journal of Photochemistry and Photobiology A: Chemistry, 2025, vol. 459, art. no. 116085.
