Name: 2-(2-(2-Azidoethoxy)ethoxy)-N-methylethanamine (97% purity)
Molecular Formula: C9H20N4O3
CAS#: 1355197-57-7
SMILES: CNCCOCCOCCOCCN=[N+]=[N-]
MDL#: MFCD29042356
Catalog#: AMTGC908-AM21-97
Molecular weight: 232.28 g/mol
Other names:
- Methylamino-PEG3-Azide
Fields of Interest: PEGylating reagent, organic synthesis, medicinal chemistry, click chemistry
Background & Applications:
Background
Methylamino-PEG3-Azide (CAS 1355197-57-7) is a short-chain, heterobifunctional azide-functionalized PEG linker built on a PEG2 backbone, incorporating a terminal azide group and a secondary amine. The polyethylene glycol spacer provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments while maintaining minimal linker length. The azide functionality supports highly efficient bioorthogonal click chemistry, including CuAAC and strain-promoted azide–alkyne cycloaddition, while the secondary amine enables selective coupling to activated carboxylic acids, NHS esters, isocyanates, and related electrophiles. This molecule is a valuable intermediate within a versatile portfolio of functionalized PEGs designed for precise molecular assembly.
Applications
Methylamino-PEG3-Azide is commonly used in bioconjugation, drug delivery, and materials science applications where compact PEG spacing and orthogonal dual reactivity are required. Typical uses include stepwise construction of multifunctional linkers, PEGylation of small molecules or polymers, and surface or nanoparticle modification via click chemistry followed by amine coupling. As part of a comprehensive functionalized PEG product line, this azido–secondary amine PEG supports modular design strategies in pharmaceutical research, diagnostics, biomaterials, and advanced materials development.
Appearance: Colorless liquid
Purity: 97%
Storage: 0-3 °C for long term storage
Solubility: DCM
Literature:
- Chemical Communications, 2022, vol. 58, # 57, p. 7928 – 7931,
- ACS Applied Nano Materials, 2023, vol. 6, # 9, p. 8105 – 8105
