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![Molecular structure for PEG 2-[2-(2-Aminoethoxy)ethoxy]ethanol (CAS 6338-55-2) from Frontier Specialty Chemicals.](https://frontierspecialtychemicals.com/wp-content/uploads/2026/02/AMTGC598-AE20-Square-510x510-1-100x100.png)
Name: 2-[2-(2-Aminoethoxy)ethoxy]ethanol (99% purity)
Molecular Formula: C6H15NO3
CAS#: 6338-55-2
SMILES: C(O)COCCOCCN
MDL#: MFCD07367495
Catalog#: AMTGC598-AE20-99
Molecular weight: 149.19g/mol
Other names:
- NH2-PEG3-OH
- (PEO)3-monoamine
- Triethylene glycol monoamine
Fields of Interest: PEGylating reagents, medicinal chemistry, organic synthesis
Background & Applications:
Background
2-[2-(2-Aminoethoxy)ethoxy]ethanol (CAS 6338-55-2) is a monofunctional amine-functionalized PEG derivative based on a PEG2 backbone, featuring a terminal primary amine and a hydroxyl group at the opposite end. The polyethylene glycol chain provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments. The primary amine enables efficient coupling to activated carboxylic acids, NHS esters, isocyanates, and related electrophiles, while the hydroxyl group offers additional derivatization options or can remain unreactive for controlled, single-point functionalization. This compact PEG intermediate is a useful member of a versatile portfolio of functionalized PEGs designed for predictable molecular modification.
Applications
2-[2-(2-Aminoethoxy)ethoxy]ethanol is commonly used in bioconjugation, drug delivery, and materials science applications where short linker length and monofunctional amine reactivity are desired. Typical uses include PEGylation of small molecules and polymers to enhance solubility and stability, preparation of multifunctional intermediates, and surface or nanoparticle modification. As part of a comprehensive functionalized PEG product line, this amine–alcohol PEG supports modular design strategies in pharmaceutical research, biomaterials development, and specialty chemical synthesis.
Appearance: Colorless Liquid
Purity: 99%
Storage: 0-3 °C for long term storage
Solubility: Soluble in DMF, DMSO, ethanol, and buffer solutions (e.g., PBS).
Literature:
Used in linker design and PEGylation strategies for research reagents and biochemical applications. Typical references in chemistry and bioconjugation literature.
- Tetrahedron, 1982, vol. 38, # 22, p. 3359 – 3362, https://doi.org/10.1016/0040-4020(82)80119-1
- Journal of Chemical Research, Miniprint, 1984, # 9, p. 2672 – 2691
