2-[2-[2-(2-Dimethylaminoethoxy)ethoxy]ethoxy]-N,N-dimethylethanamine (99%)

Name: 2-[2-[2-(2-Dimethylaminoethoxy)ethoxy]ethoxy]-N,N-dimethylethanamine (99%) 

Molecular Formula: C12H28N2O3 

CAS#: 57602-06-9 

SMILES: CN(C)CCOCCOCCOCCN(C)C 

MDL#: none found 

Catalog#: AMTGC1174-DA23 

Molecular weight:     248.36 g/mol 

Other names: 

• tetra-N-methyl-3,6,9-trioxa-undecanediyldiamine
• PEG3 bis(dimethylamine)
• Dimethylamino-PEG3-dimethylamine
• PEG3 tertiary amine linker

Fields of Interest: PEGylation, materials science, polymer modification, drug delivery 

Background & Applications:  

Background
2-[2-[2-(2-Dimethylaminoethoxy)ethoxy]ethoxy]-N,N-dimethylethanamine (CAS 57602-06-9) is a multifunctional amine-functionalized PEG derivative based on a PEG3 backbone, incorporating tertiary amine functionality (N,N-dimethylamino groups) within a short polyethylene glycol spacer. The PEG segment provides hydrophilicity, flexibility, and compatibility with aqueous and organic systems, while the tertiary amines impart tunable basicity and can support salt formation for improved handling and solubility. Because tertiary amines are not typically used for direct amide coupling like primary amines, this compound is often positioned as a specialized intermediate within a broader portfolio of functionalized PEGs where amine basicity, ionic character, or downstream quaternization is desired. 

Applications
This tertiary-amine PEG derivative is commonly used in materials science, polymer modification, and drug delivery research where cationic or ionizable linkers are needed. Typical uses include preparation of ionizable intermediates, generation of quaternary ammonium PEG species via alkylation for cationic materials, incorporation into polymers to adjust hydrophilicity and charge, and formulation-oriented applications where PEG spacing and basic functionality aid solubility or interactions with acidic components. As part of a comprehensive functionalized PEG product line, 2-[2-[2-(2-Dimethylaminoethoxy)ethoxy]ethoxy]-N,N-dimethylethanamine supports modular design strategies for advanced materials and specialty chemical synthesis requiring cationic or ionizable PEG linkers. 

Appearance: Colorless liquid 

Purity: 99% 

Storage: 0-3 °C for long term storage 

Solubility: DCM, Chloroform, MeOH 

Literature:  

1. Russian Journal of Organic Chemistry, 1995, vol. 31, # 5, p. 609 – 612 
2. Zhurnal Organicheskoi Khimii, 1995, vol. 31, # 5, p. 660 – 664