1-Azido-2-(2-(2-(2-azido ethoxy)ethoxy)ethoxy)ethane (98%)

Name: 1-Azido-2-(2-(2-(2-azido ethoxy)ethoxy)ethoxy)ethane (98% purity) 

Molecular Formula: C8H16N6O3 

CAS#: 101187-39-7 

SMILES: [N-]=[N+]=NCCOCCOCCOCCN=[N+]=[N-] 

MDL#: MFCD03425545 

Catalog#: AMTGC156-AA15-98 

Molecular weight: 244.25 g/mol 

Other names: 

• 1,11-diazido-3,6,9-trioxaundecane 

• N3-PEG3-CH2CH2N3 

Fields of Interest: PEGylating reagent, Organic Synthesis, Medicinal Chemistry 

Background & Applications:  

Background
1,11-Diazido-3,6,9-trioxaundecane is a symmetrical, low–molecular weight diazide-functionalized PEG linker based on a PEG3 backbone. The molecule features azide groups at both termini, enabling highly efficient and selective bioorthogonal click chemistry reactions, including CuAAC and strain-promoted azide–alkyne cycloaddition. The PEG spacer imparts flexibility, hydrophilicity, and reduced steric hindrance, making this compound an important intermediate within a versatile line of functionalized PEGs for controlled molecular coupling and network formation. 

Applications
This diazido PEG linker is commonly used in crosslinking, polymer modification, and bioconjugation workflows. Typical applications include the construction of PEG-based hydrogels, surface and material functionalization, and the assembly of multifunctional macromolecules via dual click reactions. 1,11-Diazido-3,6,9-trioxaundecane is also valuable in drug delivery, biomaterials, and advanced materials science, where precise spacing and orthogonal reactivity are required. As part of a comprehensive functionalized PEG product line, it supports modular design strategies for research, pharmaceutical development, and specialty chemical applications. 

Appearance: Amber liquid 

Purity: 98% 

Storage: 0-3 °C for long term storage 

Solubility: EtOAc 

Literature:  

1. European Journal of Organic Chemistry, 2019, vol. 2019, # 14, p. 2560 – 2565 

1. Journal of Medicinal Chemistry, 2023, vol. 66, # 2, p. 1467 – 1483