Name: 1, 11-Diamine-3,6,9-trioxaundecane (99%)
Molecular Formula: C8H20N2O3
CAS#: 929-75-9
SMILES: NCCOCCOCCOCCN
MDL#: MFCD00628164
Catalog#: AMTGC222-DA16-99
Molecular weight: 192.26 g/mol
Other names:
- 1: 2-[2-[2-[2-aminoethoxy]ethoxy]ethoxy]ethylamine
Fields of Interest: PEGylating reagent, Organic Synthesis, Medicinal Chemistry
Background & Applications:
Background
1,11-Diamine-3,6,9-trioxaundecane is a symmetrical diamino-functionalized PEG linker based on a PEG3 backbone, featuring primary amine groups at both termini. The polyethylene glycol spacer provides hydrophilicity, flexibility, and reduced steric hindrance, making the molecule well suited for reactions in aqueous and biological environments. The two reactive amine groups enable efficient coupling to activated carboxylic acids, NHS esters, isocyanates, and other electrophiles. This bifunctional PEG linker is a core building block within a versatile portfolio of functionalized PEGs designed for controlled crosslinking and molecular assembly.
Applications
1,11-Diamine-3,6,9-trioxaundecane is widely used in crosslinking, bioconjugation, and materials science applications. Typical uses include the synthesis of PEG-based hydrogels, preparation of polymer and surface-modified materials, and construction of multifunctional intermediates for drug delivery and biomaterials research. As part of a comprehensive functionalized PEG product line, this diamino PEG linker supports modular design strategies where precise spacing, dual reactivity, and reproducible coupling are required in pharmaceutical development and specialty chemical applications.
Appearance: Colorless liquid
Purity: 99%
Storage: 0-3 °C for long term storage
Solubility: DCM, Methanol
Literature: Advanced Optical Materials, 2025, vol. 13, # 3, art. no. 2401920.
