11-Azido-3,6,9-trioxaundecan-1-amine (98%)

COMING SOON: 99% 11-Azido-3,6,9-trioxaundecan-1-amine

Name: 11-Azido-3,6,9-trioxaundecan-1-amine (98% purity) 

Molecular Formula: C8H18N4O3 

CAS#: 134179-38-7 

SMILES: NCCOCCOCCOCCN=[N+]=[N-] 

MDL#: MFCD00269874 

Catalog#: AMTGC125-AT15-98 

Molecular weight: 218.26 g/mol 

Other names: 

• 1-AMINO-11-AZIDO-3,6,9-TRIOXAUNDECANE 

Fields of Interest: PEGylating reagent/PEGylation, organic synthesis, medicinal chemistry 

Background & Applications: 

PEG 11-Azido-3,6,9-trioxaundecan-1-amine is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal azide group and a primary amine separated by a defined PEG11 spacer. The PEG backbone provides excellent aqueous solubility, flexibility, and biocompatibility, while reducing non-specific interactions in biological systems. The azide functionality enables efficient bioorthogonal conjugation via click chemistry (e.g., CuAAC or strain-promoted reactions), and the amine group offers versatile reactivity toward NHS esters, activated carboxylic acids, and isocyanates. This combination makes PEG 11-Azido-Amine a valuable building block within a broad portfolio of functionalized PEGs designed for precision molecular assembly. 

Applications
PEG 11-Azido-3,6,9-trioxaundecan-1-amine is widely used in bioconjugation, drug delivery, and materials science applications. Typical uses include site-specific attachment of PEG chains to peptides, proteins, nanoparticles, and surfaces, development of PEGylated drug candidates, and construction of multifunctional linkers for diagnostics and imaging agents. As part of a comprehensive line of functionalized PEG linkers, this compound supports customizable spacer lengths and end-group chemistries for advanced research, pharmaceutical development, and specialty materials innovation. 

Appearance: Pale yellow liquid 

Purity: 98% 

Storage: -20 °C 

Solubility: DCM 

Literature:  

1. Tetrahedron Letters, 2023, vol. 118, art. no. 15439 

1. Journal of the American Chemical Society, 2015, vol. 137, # 16, p. 5629 – 563