Name: 1-Azido-2-(2-ethoxyethoxy)ethane (97%)
Molecular Formula: C6H13N3O2
CAS#: 215181-67-2
SMILES: CCOCCOCCN=[N+]=[N-]
MDL#: MFCD24455921
Catalog#: AMTGC289-EE17
Molecular weight: 159.19 g/mol
Other names:
- 2-(2-Ethoxyethoxy)ethyl azide
- Ethoxy-PEG2-azide
- Azido-PEG2-ethyl ether
Fields of Interest: PEGylation, click chemistry, bioconjugation, surface modification, materials science
Background & Applications:
Background
1-Azido-2-(2-ethoxyethoxy)ethane (CAS 215181-67-2) is a monofunctional azide-functionalized PEG derivative based on a PEG2 backbone, featuring a terminal azide group and an ethoxy-capped end. The polyethylene glycol chain provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments, while the ethoxy terminus remains non-reactive to allow controlled, single-point functionalization. The azide functionality enables efficient bioorthogonal click chemistry, including CuAAC and strain-promoted azide–alkyne cycloaddition. This compound serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for predictable molecular modification.
Applications
1-Azido-2-(2-ethoxyethoxy)ethane is commonly used in bioconjugation, surface modification, and materials science applications where monofunctional azide reactivity and compact PEG spacing are required. Typical uses include click-based attachment of PEG chains to small molecules, polymers, or surfaces to enhance solubility and reduce non-specific interactions, as well as preparation of PEGylated probes and intermediates for diagnostics and imaging. As part of a robust functionalized PEG product line, this ethoxy-capped azido PEG supports modular design strategies for pharmaceutical research, biomaterials development, and specialty chemical synthesis.
Appearance: Colorless liquid
Purity: 97%
Storage: 0-3 °C for long term storage
Solubility: DCM, Chloroform, MeOH
Literature:
- Organic Letters, 2013, vol. 15, # 22, p. 5870 – 5873
- Journal of the American Chemical Society, 2015, vol. 137, # 51, p. 16196 – 16202
