Name: 1-Azido-2-(2-(2-ethoxyethoxy)ethoxy)ethane (98%)
Molecular Formula: C8H17N3O3
CAS#: 215181-72-9
SMILES: CCOCCOCCOCCN=[N+]=[N-]
MDL#: MFCD30738291
Catalog#: AMTGC286-EZ17
Molecular weight: 203.24 g/mol
Other names:
- 1-Azido-PEG3-ethyl ether
- 2-(2-(2-Ethoxyethoxy)ethoxy)ethyl azide
- Azidoethyl triethylene glycol ethyl ether
- Ethoxy-PEG3-azide
- PEG3 ethyl ether azide
- Azido-PEG3-ethyl ether
Fields of Interest: PEGylation, click chemistry, surface modification, materials science
Background & Applications:
Background
1-Azido-2-(2-(2-ethoxyethoxy)ethoxy)ethane (CAS 215181-72-9) is a monofunctional azide-functionalized PEG derivative based on a PEG3 backbone, featuring a terminal azide group and an ethoxy-capped end. The polyethylene glycol chain provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments, while the ethoxy terminus remains non-reactive to allow controlled, single-point functionalization. The azide functionality enables efficient bioorthogonal click chemistry, including CuAAC and strain-promoted azide–alkyne cycloaddition. This compound serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for predictable molecular modification.
Applications
1-Azido-2-(2-(2-ethoxyethoxy)ethoxy)ethane is commonly used in bioconjugation, surface modification, and materials science applications where monofunctional azide reactivity and defined PEG spacing are required. Typical uses include click-based attachment of PEG chains to small molecules, polymers, or surfaces to enhance solubility and reduce non-specific interactions, as well as preparation of PEGylated probes and intermediates for diagnostics and imaging. As part of a robust functionalized PEG product line, this ethoxy-capped azido PEG supports modular design strategies for pharmaceutical research, biomaterials development, and specialty chemical synthesis.
Appearance: Light pink liquid
Purity: 98%
Storage: 0-3 °C for long term storage
Solubility: DCM, Chloroform, MeOH
Literature:
- Journal of Polymer Science, Part A: Polymer Chemistry, 2017, vol. 55, # 3, p. 485 – 494
- Bulletin of the Chemical Society of Japan, 2021, vol. 94, # 3, p. 790 – 797
