DMOG (Dimethyloxalylglycine)

DMOG, also known as Dimethyloxalylglycine

D1070 Dimethyloxalylglycine TDS

D1070 Dimethyloxalylglycine SDS

CAS: 89464-63-1

MDL: MFCD05865098

Fields of Interest: Hypoxia inducer, Hypoxia Signaling, 2-OG-dependent dioxygenase inhibitor, HIF-alpha prolyl hydroxylase

Background: Dimethyloxalylglycine, also known as DMOG, is a glycine diester derivative that plays a role in neuroprotection inhibiting HIF-alpha prolyl hydroxylase.^1,2   It is known as a hypoxia-mimetic and is widely used to study oxygen adaptive responses in cells. ^3,4

Molecular weight: 175.14 g/mol

Molecular Formula: C₆H₉NO₅

CAS Number:  89464-63-1

Storage: Store at –20 °C, under dry conditions.

Synonyms:

• dimethyloxalylglycine
• DMOG cpd
• N-(carboxycarbonyl)glycine
• N-oxalylglycine
• oxaloglycine
• oxalylglycine

References:   

1.)  King Hamish W, Michael Michael Z, Gleadle Jonathan M, Hypoxic enhancement of exosome release by breast cancer cells, BMC cancer (2012), 12421.

2.)  Eckle, Tobias, Koehler, David, Lehmann, Rainer, El Kasmi, Karim C., Eltzschig, Holger K., Hypoxia-Inducible Factor-1 is Central to Cardioprotection, Circulation (2008), 118(2), 166-175.

3.)  Chen, Haobin, Yan, Yan, Davidson, Todd L., Shinkai, Yoichi, Costa, Max, Hypoxic Stress Induces Dimethylated Histone H3 Lysine 9 through Histone Methyltransferase G9a in Mammalian Cells, Cancer Research (2006), 66(18), 9009-9016.

4.)  Koditz Jens, Nesper Jutta, Wottawa Marieke, Stiehl Daniel P, Camenisch Gieri, Franke Corinna, Myllyharju Johanna, Wenger Roland H, Katschinski Dorthe M , Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor, Blood (2007), 110(10), 3610-7.